Smokovo Thermal Springs is a small settlement 35 km southwestern of Karditsa in the massif of Southern Agrafa and in the height of 450 m. It was named after the nearby sulfur-alkaline hot springs, whose properties have been known since antiquity. More specifically they are recommended for disorders of the respiratory and digestive system, skin diseases, chronic rheumatism-arthritis, endocrine deficiencies, gynecological diseases and of course for relaxation, rejuvenation and wellness. The spa features a sauna-steam room, swimming pool, gym, massage, rinoplysis, balneotherapy, etc. In recent years, near the baths has created the artificial lake of Smokovo, because of which it has developed the flora and the fauna of the area and the nearby destinations that the visitors deserve to see are many. Such villages are Loutropigi (Smokovo), Aidonochori, Vathylakio and Thrapsimi, located in lush forests of beeches, oaks, cedars and agelong trees. They also have accommodation, restaurants and local materials which are used to organize cultural events during summer. For those who are interested in religious tourism, are suggested Rendina Monastery, the Monastery in Domianoi and Prousou Monastery (about 30 km from Karpenisi). In Rendina there also is the Museum of National Resistance.